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Exam 6: Genetic Linkage and Mapping in Eukaryotes

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Question 1

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In a given mapping experiment, you expect that incidence of double crossovers is 3.5%, but you only observe 2.5%. This can be explained by ________.

A) interference
B) linkage
C) coincidence
D) segregation

E) B) and D)
F) B) and C)

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A

Question 2

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If two loci are extremely linked, then no recombination is expected.

A) True
B) False

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Question 3

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Which of the following procedures may be used to map genes in a fungi with an unordered tetrad ascus?

The middle gene of a three gene mapping experiment can be determined by examining the genotypes of which of the following?

A map distance of 23.6 between two genes indicates which of the following?

Following crossing-over, chromosomes with genetic combinations that resemble the parents' chromosomes are called nonrecombinant.

In a chi-square test to determine if two genes are linked or assorting independently, what is the default (null) hypothesis that is tested?

The number of linkage groups in a species that does not have sex chromosomes is: Where n equals the haploid number of autosomes.

In a mapping experiment with three linked genes, which phenotype should occur most often in the F2 offspring?

If you want to determine how the alleles of different loci interact in their various combinations, it is best to have a system where you do not have to worry about dominance and recessiveness. Which of the following would represent a system where you do not have to worry about dominance and recessiveness?

The first observational evidence that genes may be inherited together rather than by simple Mendelian inheritance was provided by ________.

The diploid garden pea plant has 14 chromosomes. The haploid fungus Neurospora crassa has 7 chromosomes. Neither organism has separate male and female individuals. Therefore, the number of linkage groups in these two organisms is

Mitotic recombination occurs between homologous chromosomes. In which of the following would you not expect to encounter mitotic recombination?

The locus B on the X chromosome of a malaria-carrying mosquito shows a 49% recombination rate with respect to the locus M. Since a recombination rate of 50% is essentially indistinguishable from independent assortment, you might be tempted to look for a locus that falls between B and M. Before you decide to do all that work, you run a chi square test to determine the P value of your experiment. Which of the following P values would be most likely to tell you that you should accept the conclusion that locus B and locus M are, indeed, 49mu apart and that another locus is not necessary?

The percentage of recombination associated with independent assortment should approximate 50%.

Map distance is the number of recombinant offspring divided by the total number of nonrecombinant offspring.

You have calculated the interference value for a given mapping experiment to be 30%. What does this mean?

The end result of meiosis in fungi is a tetrad of spores.

The number of linkage groups in an organism with sex chromosomes equals ________, where n equals the haploid number of autosomes.

In a mapping cross, you determine that the recombination frequency between: loci Q and P is 12% Loci Q and L is 15%. If locus Q is in between loci P and L, then the recombination frequency between P and L should be approximately