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The difference between phenotype and genotype is that


A) phenotype refers to the genetic instructions and genotype to their expression.
B) genotype refers to the genetic instructions and phenotype to their expression.
C) the phenotype is RNA and the genotype is DNA.
D) the phenotype is DNA and the genotype is RNA.
E) the phenotype appears before the genotype is set.

F) All of the above
G) B) and C)

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B

A chart that displays paired chromosomes in size order is a


A) pedigree.
B) phenotype.
C) genotype.
D) genotree.
E) genome.

F) B) and C)
G) B) and D)

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The four basic tissue types are


A) blood cells, skin cells, neurons, and muscle cells.
B) DNA, RNA, proteins, and lipids.
C) adipose cells, muscle cells, bone cells, and sex cells.
D) connective tissue, epithelium, muscle, and nervous tissue.
E) the stomach, the small intestine, the liver, and the pancreas.

F) A) and D)
G) C) and E)

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Constructing a "diseasome" is a way to connect diseases that share certain gene expression patterns.A goal of this approach is to


A) cure cancer.
B) identify new drug targets.
C) cure all diseases that involve the same set of genes.
D) discover how our long-ago ancestors were related.
E) determine which populations have which diseases.

F) A) and B)
G) A) and C)

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The largest autosome is


A) the Y chromosome.
B) the X chromosome.
C) chromosome 22.
D) chromosome 1.
E) chromosome 14.

F) A) and B)
G) A) and E)

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In general,RNA molecules


A) comprise the chromosomes.
B) use the information in specific DNA sequences to construct proteins.
C) use the information in specific proteins to construct DNA molecules.
D) entwine with DNA molecules to encode proteins.
E) form double helices that encode DNA sequences.

F) All of the above
G) B) and E)

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Neka is part Native American.He has several relatives who have alcoholism.Neka takes a direct-to-consumer genetic test panel and discovers that he has inherited gene variants that are associated with increased risk of alcoholism.He reports these facts during an interview for purchasing a life insurance policy,because he thinks that the Genetic Information Nondiscrimination Act will protect him from being denied life insurance based on results of a genetic test.Alas,Neka is denied coverage,because


A) the law does not protect Native Americans.
B) the law does not protect people of mixed lineage.
C) the law only applies to health insurance and employers, not life insurance.
D) the law does not apply to direct-to-consumer tests.
E) GINA does not take effect until 2014.

F) B) and D)
G) C) and D)

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A gene pool consists of all the alleles in a(n)


A) population.
B) individual.
C) family.
D) neighborhood.
E) nation.

F) All of the above
G) A) and C)

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The number of copies of our genome in most of our cells is __.


A) 1
B) 2
C) 3
D) 4
E) 5

F) C) and D)
G) D) and E)

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B

Genetics is the study of


A) variation of inherited traits.
B) how organisms reproduce.
C) how life originated.
D) how the environment causes disease.
E) the chemical composition of cells.

F) All of the above
G) B) and D)

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A

A change in a gene's DNA sequence is a(n)


A) allele.
B) genotype.
C) nucleotide.
D) mutation.
E) genome.

F) None of the above
G) D) and E)

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Nacho suffers from terrible migraine headaches.He enters a clinical trial to test whether certain single nucleotide polymorphisms (SNPs) are associated with response to one drug but not another.This is an approach called


A) gene therapy.
B) pharmacogenomics.
C) genetic determinism.
D) applied pharmacology.
E) genotherapy.

F) A) and B)
G) B) and D)

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One way to study the human genome is to


A) determine the twisting patterns of the two sides of the double helix.
B) determine the sequence of sugars and phosphates.
C) determine the DNA sequence.
D) conduct a phenotype-wide association study.
E) mix the genomes of two individuals.

F) A) and B)
G) A) and C)

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In a study,3,794 of 4,000 people who have acne have a particular set of SNPs.Only 184 of 3,984 people who do not have acne,but are otherwise similar to the people with acne,have that SNP pattern.Therefore,these parts of the genome with this SNP pattern may include genes whose products affect the skin.This investigation is an example of a


A) genome sequencing experiment.
B) genome-wide association study.
C) genome-wide mutation study.
D) gene expression profile.
E) pharmacogenomics study.

F) A) and B)
G) All of the above

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A melon that has been altered to produce a protein normally made only in a cabbage is


A) transformed.
B) transgenic.
C) genomic.
D) transgendered.
E) recessive.

F) A) and B)
G) None of the above

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Gene expression profiles of different cell types reflect different sets of


A) genes.
B) mRNAs.
C) proteins.
D) genomes.
E) SNPs.

F) A) and C)
G) B) and D)

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The complete genetic material of an organism is its


A) genome.
B) chromosome.
C) phenotype.
D) genotype.
E) proteome.

F) B) and E)
G) A) and C)

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An estimated _____ DNA base pairs comprise the human genome.


A) 32,000
B) 320,000
C) 3.2 million
D) 3.2 billion
E) 3.2 trillion

F) C) and D)
G) A) and E)

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A single nucleotide polymorphism is


A) an individual's genotype for a particular trait.
B) a single base site in the genome that varies among individuals in a population.
C) a single copy of a gene.
D) a gene that is expressed differently in males and females.
E) the DNA base that begins a gene.

F) C) and D)
G) D) and E)

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DNA profiling has been used to


A) identify victims of terrorist attacks and natural disasters.
B) cure metabolic diseases caused by mutations in single genes.
C) treat male infertility.
D) predict how children will do in school.
E) predict if someone will develop cancer.

F) A) and D)
G) A) and C)

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