Question 1

Which of the following would be an expected finding in the bone marrow in a patient with the following results: serum iron = 124 ug/dL (reference range: 35-170 ug/dL) ; TIBC = 284 ug/dL (reference range: 225-425 ug/dL) ?

Accepted Answer

A)  Decreased or absent Prussian blue specks
B)  Adequate iron stores with Prussian blue stain
C)  Sea blue histiocytes
D)  Increased iron storesE) B) and D)
F) A) and D)

Question 2

A 2-year-old boy is suspected of having leukemia, and a bone marrow examination is requested.From which body site should the bone marrow be collected?

Accepted Answer

A)  Superior iliac crest
B)  Vertebrae
C)  Tibia
D)  SternumE) All of the above
F) A) and B)

Question 3

The M:E ratio is determined by examining the relationship between:

Accepted Answer

A)  Myeloid precursors and erythroid and lymphoid precursors.
B)  Myeloid precursors and lymphoid precursors.
C)  Megakaryocytic precursors and nucleated erythroid precursors.
D)  All granulocytic precursors and nucleated erythroid precursors.E) None of the above
F) B) and C)

Question 4

The assays below are typically performed on bone marrow specimens.Match each assay with the appropriate specimen type, assuming both are available.
A)Bone marrow differential
B)M:E ratio
C)Cellularity
D)Assessment of iron stores

Accepted Answer

Bone marrow differential: bone marrow as...

Question 5

A differential is performed on a bone marrow specimen obtained from a patient suspected of having CML in blast crisis.The results are as follows: 45% blasts, 13% metamyelocytes, 18% myelocytes, 10% promyelocytes, 8% bands, 2% segmented neutrophils, 1% pronormoblasts, 1% basophilic normoblasts, 1% polychromatophilic normoblasts, and 1% orthochromatophilic normoblasts.What is the M:E ratio?

Accepted Answer

A)  2:1
B)  24:1
C)  12:1
D)  15:1E) C) and D)
F) All of the above

Question 6

The cellularity of the bone marrow is determined by examining the ratio of:

Accepted Answer

A)  Stromal cells to hematopoietic cells.
B)  Hematogones to hematopoietic cells.
C)  Adipose tissue to hematopoietic cells.
D)  Hematopoietic cells to non-hematopoietic cells.E) A) and B)
F) All of the above

Question 7

Which of the following is required information on a bone marrow report?

Accepted Answer

A)  Site of sampling and type of sample(s)  obtained
B)  Side-by-side comparison of bone marrow differential and peripheral blood differential results
C)  Results of ancillary studies
D)  All of the aboveE) C) and D)
F) B) and D) D

Question 8

What is the difference between a malignant lymphoid aggregate and a benign lymphoid aggregate?

Accepted Answer

A)  Benign aggregates are well defined, whereas malignant aggregates are ill-defined.
B)  Malignant aggregates are composed of single polymorphic cells, whereas benign aggregates are composed of multiple monomorphic cells.
C)  Benign aggregates are clonal, whereas malignant aggregates are polyclonal.
D)  Malignant aggregates have a normal phenotype and benign have an aberrant phenotype.E) A) and D)
F) A) and C)

Question 9

The Prussian blue stain is used to stain what element?

Accepted Answer

A)  Organelle-associated enzymes
B)  Carbohydrates
C)  Iron
D)  ProteinsE) A) and D)
F) C) and D)

Question 10

A bone marrow core biopsy is received on a 10-year-old male patient suspected of having aplastic anemia.The pathologist reviews the smear and concludes the overall cellularity to be 22% with an M:E ratio of 2.5:1.Is the patient likely suffering from aplastic anemia? Why or why not?

Accepted Answer

A)  There is not enough information to determine whether the patient has aplastic anemia.
B)  Yes, the patient is presumably suffering from aplastic anemia, but the M:E ratio does not correlate well with the diagnosis of aplastic anemia.
C)  No, the patient is not suffering from aplastic anemia, because the overall cellularity is increased.
D)  Yes, the patient may be suffering from aplastic anemia, due to the low overall cellularity and the normal M:E ratio.E) A) and B)
F) A) and C)

Question 11

The presence of which of the following in the bone marrow is diagnostic for sideroblastic anemia?

Accepted Answer

A)  Iron-laden macrophages
B)  Sea blue histiocytes
C)  Moderate siderocytes
D)  Ringed sideroblastsE) A) and D)
F) A) and C) D

Question 12

A low M:E ratio in a patient represents what possible process?

Accepted Answer

A)  Erythroid hypoplasia
B)  Erythroid hyperplasia
C)  Myeloid hyperplasia
D)  CMLE) B) and C)
F) None of the above

Question 13

What are the primary uses of flow cytometry in the evaluation of hematologic disorders?

Accepted Answer

A)  To detect the presence of clonality, and diagnose and classify malignant lymphomas and leukemias
B)  Classifying anemias associated with defective hemoglobin synthesis
C)  Identifying specific genetic rearrangements
D)  To detect chromosomal alterationsE) A) and C)
F) None of the above

Question 14

What would be the expected effect of chronic myelogenous leukemia on the M:E ratio?

Accepted Answer

A)  Normal M:E ratio
B)  Increased M:E ratio
C)  Decreased M:E ratio
D)  No effect on the M:E ratioE) C) and D)
F) B) and D)

Question 15

It has been determined that the M:E ratio of a 55 year old patient is 12:1.What can be concluded about the cellularity of the bone marrow?

Accepted Answer

A)  The bone marrow has myeloid hyperplasia.
B)  The bone marrow has erythroid hyperplasia.
C)  The bone marrow is normal.
D)  The overall cellularity of the marrow is hypercellular.E) None of the above
F) A) and C)

Question 16

The cellularity of the marrow is best examined in ________, and it is determined by the red bone marrow's relationship to _________.

Accepted Answer

A)  BM aspirate; the patient's age
B)  BM aspirate; hematogones
C)  BM biopsy; yellow marrow
D)  BM biopsy; stromal cellsE) B) and D)
F) B) and C)

Question 17

Which of the following indicates a reason for performing cytochemical staining on bone marrow specimens of suspected hematologic dyscrasias?

Accepted Answer

A)  Cytochemical staining has higher specificity for hematopoietic lineage differentiation than does standard morphology.
B)  Cytochemical staining has lower incidence of false negatives in detecting malignancies..
C)  Manual differentials are prone to misinterpretation, whereas cytochemical staining does not have these errors.
D)  Cytochemical staining provides a better overview of bone marrow status of hematopoiesis than does the manual differential.E) A) and C)
F) B) and C)

Question 18

What cells are examined for morphologic characteristics of iron particles in the diagnosis of myelodysplastic syndrome?

Accepted Answer

A)  Leukocytes
B)  Erythrocytes
C)  Histiocytes and red cell precursors
D)  LymphocytesE) A) and B)
F) All of the above C

Question 19

One morphological difference between benign lymphoid aggregates and malignant lymphoma is that malignant aggregates are:

Accepted Answer

A)  Well defined.
B)  Ill defined, and small to large.
C)  Diffuse and patchy.
D)  Well defined with plasma cells.E) A) and B)
F) A) and C)

Question 20

The primary location for bone marrow collection is dependent on which two factors?

Accepted Answer

A)  Age and patient condition
B)  Change in sites of hematopoiesis and cellularity
C)  The M:E ratio and medical history
D)  Age and medical historyE) All of the above
F) B) and D)

Exam 34: Bone Marrow Examination

Which of the following would be an expected finding in the bone marrow in a patient with the following results: serum iron = 124 ug/dL (reference range: 35-170 ug/dL) ; TIBC = 284 ug/dL (reference range: 225-425 ug/dL) ?

Correct Answer
verified

A 2-year-old boy is suspected of having leukemia, and a bone marrow examination is requested.From which body site should the bone marrow be collected?

Correct Answer
verified

The M:E ratio is determined by examining the relationship between:

Correct Answer
verified

The assays below are typically performed on bone marrow specimens.Match each assay with the appropriate specimen type, assuming both are available. A)Bone marrow differential B)M:E ratio C)Cellularity D)Assessment of iron stores

Correct Answer
verified
Bone marrow differential: bone marrow as...
View Answer

Correct Answer
verified

The cellularity of the bone marrow is determined by examining the ratio of:

Correct Answer
verified

Which of the following is required information on a bone marrow report?

Correct Answer
verified
D

What is the difference between a malignant lymphoid aggregate and a benign lymphoid aggregate?

Correct Answer
verified

The Prussian blue stain is used to stain what element?

Correct Answer
verified

A bone marrow core biopsy is received on a 10-year-old male patient suspected of having aplastic anemia.The pathologist reviews the smear and concludes the overall cellularity to be 22% with an M:E ratio of 2.5:1.Is the patient likely suffering from aplastic anemia? Why or why not?

Correct Answer
verified

The presence of which of the following in the bone marrow is diagnostic for sideroblastic anemia?

Correct Answer
verified
D

A low M:E ratio in a patient represents what possible process?

Correct Answer
verified

What are the primary uses of flow cytometry in the evaluation of hematologic disorders?

Correct Answer
verified

What would be the expected effect of chronic myelogenous leukemia on the M:E ratio?

Correct Answer
verified

It has been determined that the M:E ratio of a 55 year old patient is 12:1.What can be concluded about the cellularity of the bone marrow?

Correct Answer
verified

The cellularity of the marrow is best examined in , and it is determined by the red bone marrow's relationship to _.

Correct Answer
verified

Which of the following indicates a reason for performing cytochemical staining on bone marrow specimens of suspected hematologic dyscrasias?

Correct Answer
verified

What cells are examined for morphologic characteristics of iron particles in the diagnosis of myelodysplastic syndrome?

Correct Answer
verified
C

One morphological difference between benign lymphoid aggregates and malignant lymphoma is that malignant aggregates are:

Correct Answer
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The primary location for bone marrow collection is dependent on which two factors?

Correct Answer
verified

Exam 34: Bone Marrow Examination

Which of the following would be an expected finding in the bone marrow in a patient with the following results: serum iron = 124 ug/dL (reference range: 35-170 ug/dL) ; TIBC = 284 ug/dL (reference range: 225-425 ug/dL) ?

Correct AnswerverifiedShow Answer

A 2-year-old boy is suspected of having leukemia, and a bone marrow examination is requested.From which body site should the bone marrow be collected?

Correct AnswerverifiedShow Answer

The M:E ratio is determined by examining the relationship between:

Correct AnswerverifiedShow Answer

The assays below are typically performed on bone marrow specimens.Match each assay with the appropriate specimen type, assuming both are available. A)Bone marrow differential B)M:E ratio C)Cellularity D)Assessment of iron stores

Correct AnswerverifiedBone marrow differential: bone marrow as...View AnswerShow Answer

Correct AnswerverifiedShow Answer

The cellularity of the bone marrow is determined by examining the ratio of:

Correct AnswerverifiedShow Answer

Which of the following is required information on a bone marrow report?

Correct AnswerverifiedD

What is the difference between a malignant lymphoid aggregate and a benign lymphoid aggregate?

Correct AnswerverifiedShow Answer

The Prussian blue stain is used to stain what element?

Correct AnswerverifiedShow Answer

A bone marrow core biopsy is received on a 10-year-old male patient suspected of having aplastic anemia.The pathologist reviews the smear and concludes the overall cellularity to be 22% with an M:E ratio of 2.5:1.Is the patient likely suffering from aplastic anemia? Why or why not?

Correct AnswerverifiedShow Answer

The presence of which of the following in the bone marrow is diagnostic for sideroblastic anemia?

Correct AnswerverifiedD

A low M:E ratio in a patient represents what possible process?

Correct AnswerverifiedShow Answer

What are the primary uses of flow cytometry in the evaluation of hematologic disorders?

Correct AnswerverifiedShow Answer

What would be the expected effect of chronic myelogenous leukemia on the M:E ratio?

Correct AnswerverifiedShow Answer

It has been determined that the M:E ratio of a 55 year old patient is 12:1.What can be concluded about the cellularity of the bone marrow?

Correct AnswerverifiedShow Answer

The cellularity of the marrow is best examined in ________, and it is determined by the red bone marrow's relationship to _________.

Correct AnswerverifiedShow Answer

Which of the following indicates a reason for performing cytochemical staining on bone marrow specimens of suspected hematologic dyscrasias?

Correct AnswerverifiedShow Answer

What cells are examined for morphologic characteristics of iron particles in the diagnosis of myelodysplastic syndrome?

Correct AnswerverifiedC

One morphological difference between benign lymphoid aggregates and malignant lymphoma is that malignant aggregates are:

Correct AnswerverifiedShow Answer

The primary location for bone marrow collection is dependent on which two factors?

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
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Correct Answer
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Correct Answer
verified
Bone marrow differential: bone marrow as...
View Answer

Correct Answer
verified

Correct Answer
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Correct Answer
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D

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Correct Answer
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Correct Answer
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Correct Answer
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D

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Correct Answer
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Correct Answer
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Correct Answer
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The cellularity of the marrow is best examined in , and it is determined by the red bone marrow's relationship to _.

Correct Answer
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Correct Answer
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Correct Answer
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C

Correct Answer
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Correct Answer
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