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A G-protein coupled receptor associates with a G protein that contains how many subunits?


A) 0
B) 1
C) 2
D) 3
E) 4

F) B) and E)
G) A) and E)

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What type of signaling occurs when insulin is secreted from the pancreas and acts on muscle cells to increase glucose uptake?


A) contact-to-contact signaling
B) intercellular signaling
C) autocrine signaling
D) paracrine signaling
E) endocrine signaling

F) B) and C)
G) All of the above

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Which of the following is NOT an example of how differential gene regulation affects cellular response?


A) The expression of proteins that are controlled by signal transduction pathways may vary in different cell types.
B) Cell junctions passing ions between the cytosol of one cell to another cell.
C) A cell may or may not express a receptor for a particular signaling molecule.
D) The expression of proteins involved in intracellular signal transduction pathways may vary in different cell types
E) Different cell types have different cell surface receptors that recognize the same signaling molecules.

F) D) and E)
G) A) and D)

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Which molecule is directly responsible for breaking down cAMP to inactive AMP?


A) protein kinase A
B) adenylyl cyclase
C) phosphodiesterase
D) GTPase
E) protein phosphatase

F) None of the above
G) B) and D)

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Which of the following order of events is most accurate for activation of G-protein coupled receptor (GPCR) signaling pathways?


A) Hormone binds GPCR, GPCR binds with G protein, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins.
B) Hormone binds GPCR, G protein loses GDP and gains GTP, GPCR binds with G protein, G-protein alpha subunit activates intracellular proteins.
C) Hormone binds GPCR, GPCR binds with G protein, G-protein alpha subunit activates intracellular proteins, G protein loses GDP and gains GTP.
D) Hormone binds GPCR, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins, GPCR binds with G protein.
E) GPCR binds with G protein, hormone binds GPCR, G protein loses GDP and gains GTP, G-protein alpha subunit activates intracellular proteins.

F) A) and E)
G) C) and E)

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Estrogen is most likely to exert its effects by regulating


A) protein kinases.
B) phopholipase C.
C) expression of genes and production of specific proteins.
D) cyclic AMP.
E) Ca2+.

F) A) and E)
G) A) and D)

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What type of receptor does IP3 bind?


A) G-protein coupled
B) ligand-gated Ca2+ channel
C) enzyme-linked
D) sensor kinase
E) phospholipase type-I

F) A) and B)
G) All of the above

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What do synaptic signaling and paracrine signaling have in common?


A) Cells release a signal that affects it and neighboring cells.
B) Cells release a signal that affects cells at long distances.
C) Cells release a signal through gap junctions to affect neighboring cells.
D) Cells bind a membrane bound signal on a neighboring cell.
E) Cells release a signal that affects neighboring cells.

F) B) and E)
G) A) and E)

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When assembling a fish aquarium one must add a conditioner to the water that contains bacteria capable of metabolizing fish waste such as ammonia, nitrate, and nitrite that accumulates in the aquaria water. Which of the following components of signal reception and transduction is NOT required for the bacterial two-component regulatory system for metabolizing these nitrogenous waste products?


A) NarQ receptor
B) NarL transcriptional activator
C) a protein kinase
D) metabolic enzymes
E) ligand-gated calcium channel

F) A) and B)
G) A) and C)

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All of the following are general components of the growth factor signaling pathway EXCEPT


A) tyrosine kinase-linked receptor.
B) GRB2-Sos-Ras complexes.
C) phosphorylated transcription factors.
D) Raf-1.
E) IP3 and Ca2+.

F) D) and E)
G) A) and E)

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Which of the following represents the correct sequence of events in the cAMP signal transduction pathway?


A) G protein?cAMP?adenylyl cyclase?protein kinase A?cell response
B) G protein?adenylyl cyclase?protein kinase A?cAMP?cell response
C) G protein?protein kinase A?adenylyl cyclase?cAMP?cell response
D) G protein?adenylyl cyclase?cAMP?protein kinase A?cell response
E) adenylyl cyclase?G protein?cAMP?protein kinase A?cell response

F) B) and C)
G) A) and D)

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Which of the following is capable of dephosphorylating molecules?


A) phospholipase C
B) protein kinase A
C) Grb2/Sos/Ras complex
D) phosphatase
E) IP3

F) A) and D)
G) A) and E)

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Which of the following is LEAST likely involved in calcium signaling?


A) IP3
B) calmodulin
C) protein kinase A
D) protein kinase C
E) phospolipase C

F) A) and E)
G) B) and E)

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During exposure to elevated glucose, a yeast cell's membrane glucose transporters will rapidly increase so the cell can import glucose. Which would represent the yeast cell response?


A) increased membrane glucose transporters
B) increased membrane glucose receptors
C) increased glucose transport into the cell
D) both increased membrane glucose transporters and glucose receptors
E) both increased membrane glucose transporters and glucose transport into the cell

F) A) and B)
G) A) and E)

Correct Answer

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Which of the following is not a common way signals are relayed between cells?


A) Contact-dependent signaling
B) Autocrine signaling
C) Direct intercellular signaling
D) Paracrine signaling
E) All of the above are ways signals are relayed between cells

F) A) and B)
G) B) and C)

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What type of cell communication is said to occur if a cell secretes a growth factor that then acts on neighboring cells to cause them to proliferate?


A) contact-to-contact signaling
B) intercellular signaling
C) autocrine signaling
D) paracrine signaling
E) endocrine signaling

F) D) and E)
G) A) and D)

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Which of the following types of molecules is LEAST involved in cell communication?


A) carbohydrates
B) lipids
C) steroids
D) proteins
E) neurotransmitters

F) A) and E)
G) A) and B)

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Once bound to a hormone, this receptor becomes active and catalyzes the transfer of a phosphate group to itself or intracellular proteins.


A) G-protein coupled receptor
B) enzyme-linked receptor
C) ligand-gated ion channel receptor
D) mechanoreceptor
E) thermoreceptor

F) D) and E)
G) A) and C)

Correct Answer

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Adenylyl cyclase is to cAMP as ________ is to IP3.


A) protein kinase A
B) protein kinase C
C) calmodulin
D) Raf1
E) phospholipase C

F) A) and C)
G) A) and B)

Correct Answer

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Apoptosis is necessary in humans in order to eliminate cells infected by viruses, cells that are worn out, and those that have the potential to cause cancer.

A) True
B) False

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