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During which phase(s) of mitosis are chromosomes composed of two sister chromatids?


A) prophase and prometaphase only
B) prophase, prometaphase, and metaphase
C) prophase, prometaphase, metaphase, and anaphase
D) anaphase and telophase only
E) all phases of mitosis

F) C) and D)
G) None of the above

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Which statement best describes the difference between cell division in plant and animal cells?


A) Cytokinesis occurs by formation of a cleavage furrow in animal cells, but not plant cells.
B) Cytokinesis occurs by formation of a cleavage furrow in plant cells, but not animal cells.
C) Centrosomes play an important role in spindle formation in plant cells, but not in animal cells.
D) Chromosome replication occurs during interphase in animal cells, while in plant cells, replication occurs when the nuclear envelope disintegrates.
E) Animal cells divide via the cell cycle whereas plant cells divide by binary fission.

F) C) and D)
G) B) and D)

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Most cancers require at least two mutations: 1) one in an oncogene, which encodes proteins that trigger cell division, and 2) one in a tumor suppressor gene, whose protein products, in their unmutated form, play a key role in preventing the cell cycle from progressing if the DNA is damaged or in the absence of specific cues. Which class of proteins might be considered tumor suppressors?


A) Cdk inhibitors
B) cyclins
C) growth factor receptors
D) microtubules
E) transcription factors

F) A) and B)
G) A) and D)

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Chromosomes are in a condensed form at which stage(s) of the cell cycle?


A) prophase only
B) prophase and metaphase
C) interphase
D) all stages of interphase and mitosis
E) throughout mitosis until late telophase

F) C) and D)
G) D) and E)

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 Figure 10.1 - Answer the following questions using the accompanying figure.  Identify the stage of mitosis shown in panel B. A)  interphase B)  prophase C)  metaphase D)  anaphase E)  telophaseFigure 10.1 - Answer the following questions using the accompanying figure. Identify the stage of mitosis shown in panel B.


A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase

F) A) and B)
G) A) and C)

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Oncogenes are often ____.


A) mutant forms of cell cycle genes
B) normal forms of cell cycle genes
C) needed for normal cells to metastasize
D) required for normal contact inhibition of cells
E) not involved in cell division

F) A) and E)
G) A) and D)

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Loosely packed regions of DNA associated with histones are called ____.


A) euchromatin
B) heterochromatin
C) chromosomes
D) nucleosomes
E) 30-nm chromatin fibers

F) D) and E)
G) C) and D)

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Chromosomes decondense into chromatin at which point in the cell cycle?


A) at the beginning of S phase
B) at the end of interphase
C) at the beginning of prophase
D) at the beginning of metaphase
E) at the end of telophase

F) A) and E)
G) B) and D)

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When growth factors bind to receptors on the cell surface, the signaling cascade will ____.


A) initiate cell growth
B) prevent cell division
C) trigger cell death
D) cause the cells to enter the G0state
E) trigger mitosis without the other stages of the cell cycle

F) A) and D)
G) B) and C)

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Compared to the parent cell, each of two daughter cells that result from normal mitotic division contains ____ chromosomes and is genetically ____.


A) the same number of; different
B) the same number of; identical
C) half the number of; different
D) half the number of; identical
E) double the number of; identical

F) A) and D)
G) All of the above

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Certain human cell types, such as skeletal muscle cells, have several nuclei per cell. Based on your understanding of mitosis, how could this happen?


A) The cell undergoes repeated cytokinesis but not mitosis.
B) The cell undergoes repeated mitotic divisions with concomitant cytokinesis.
C) The cell undergoes repeated mitotic divisions but not cytokinesis.
D) The cell undergoes anaphase twice before entering telophase.
E) The cell goes through multiple S phases before entering mitosis.

F) C) and D)
G) None of the above

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At the conclusion of S phase, a diploid cell with 40 chromosomes will have ____ chromosomes and _____ sister chromatids.


A) 20; 40
B) 20; 20
C) 40; 40
D) 40; 80
E) 80; 80

F) A) and B)
G) B) and D)

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The separation of duplicated chromosomes into two new nuclei is known as ____.


A) mitosis
B) cytokinesis
C) binary fission
D) meiosis
E) fertilization

F) A) and D)
G) A) and E)

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Colchicine, a chemical extracted from the autumn crocus (C olchicum autumnale ) , inhibits the formation of microtubules. Mitotic cells exposed to colchicine will therefore be arrested at ____.


A) anaphase
B) interphase
C) prophase
D) telophase
E) metaphase

F) C) and D)
G) C) and E)

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E

In order to understand how chromosomes move during anaphase of mitosis, researchers tagged ____ with a fluorescent label before photobleaching the cell and examining chromosomal movement under a microscope.


A) DNA
B) kinetochore microtubules
C) nonkinetochore microtubules
D) histones
E) motor proteins

F) A) and E)
G) C) and D)

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Organisms that reproduce asexually usually do so through the process of ____.


A) mitosis
B) meiosis
C) gametogenesis
D) spore formation
E) fertilization

F) B) and C)
G) A) and B)

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In plants, the microtubules organizing centers are comprised of microtubules.

A) True
B) False

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True

One of the three internal cell cycle checkpoints occurs during ____ and monitors ____.


A) the G1/S transition; mitotic spindle integrity
B) late S phase; the presence of DNA damage
C) the G2/M transition; the presence of DNA damage
D) the G2/M transition; mitotic spindle integrity
E) anaphase; the presence of DNA damage

F) A) and B)
G) A) and C)

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 Figure 10.1 - Answer the following questions using the accompanying figure.  Identify the stage of mitosis shown in panel E. A)  interphase B)  prophase C)  metaphase D)  anaphase E)  telophaseFigure 10.1 - Answer the following questions using the accompanying figure. Identify the stage of mitosis shown in panel E.


A) interphase
B) prophase
C) metaphase
D) anaphase
E) telophase

F) A) and D)
G) A) and E)

Correct Answer

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Embryonic development begins with a single egg fertilized by a single sperm, forming a zygote which then divides by mitosis. How many cells are present in the embryo at the conclusion of four mitotic divisions?


A) 2
B) 4
C) 8
D) 16
E) 32

F) A) and D)
G) B) and E)

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D

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