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Exam 4: Inheritance Patterns of Single Genes and Gene Interaction

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Question 31

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The four different human blood types are caused by how many different alleles? What are the alleles?

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three: IA,...

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Question 32

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A mutation results in an enzyme that is partially active compared to the wild- type allele. This type of "leaky" mutation is classified as _______.

A) null/ amorphic
B) hypomorphic
C) hypermorphic
D) neomorphic
E) dominant negative

F) None of the above
G) A) and B)

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Question 33

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You are looking at the color of feathers in ducks and find that yellow ducks (Y) are dominant to green ducks (y) . However, a second gene, H, controls whether the color will be expressed in the feathers. If the duck is hh, the duck will always be white, because the pigment does not go into feathers. What ratio of phenotypes would you expect following a dihybrid cross?

Gene interactions in which an allele of one gene modifies or prevents expression of alleles of another gene is known as_______ .

Brachydactyly type D is human autosomal dominant condition in which the thumbs are abnormally short and broad. In most cases, both thumbs are affected, but occasionally just one thumb is involved. The pedigree above shows a family in which brachydactlyly type D is segregating. Filled circles and squares represent females and males who have involvement of both thumbs. Half- filled in symbols represent family members with just one thumb affected? There is evidence of variable expressivity and incomplete penetrance in this family. Which individu most likely nonpenetrant for the trait?

Most combinations of different ABO alleles result in complete dominance of one allele. Which combination results in codominance?

Brachydactyly type D is human autosomal dominant condition in which the thumbs are abnormally short and broad. In most cases, both thumbs are affected, but occasionally just one thumb is involved. The pedigree above shows a family in which brachydactlyly type D is segregating. Filled circles and squares represent females and males who have involvement of both thumbs. Half- filled in symbols represent family members with just one thumb affected? There is evidence of variable expressivity and incomplete penetrance in this family. Which individu most likely nonpenetrant for the trait?

King George III of England and other members of the royal family were afflicted with a series of strange, seemingly unrelated symptoms including abdominal pain, rapid pulse, convulsions, and insanity. It has been determined that he likely suffered from porphyria, caused by a mutation in a single allele. What is the genetic term describing the alteration of multiple, distinct traits of an organism by a mutation in a single gene?

Which mode of inheritance produces heterozygotes with phenotypes that differ from either homozygote but typically more closely resembles one homozygous phenotype than the other?

Proper cross- matching of blood type is essential for safe blood transfusion. What is the general rule for safe blood transfusion, and what are the consequences if a patient receives the incorrect blood type by accident? If a patient's blood type is unknown, what is the safest course of action?

A mutation resulting in an inactive gene product is classified as _________.

In sheep, coat color is influenced by two genes. Gene A influences pigment production, while gene B produces black or brown pigment. If two heterozygous white sheep resulted in 12 white sheep, 3 black sheep, and 1 brown sheep, which genotype(s) of the white sheep explain this data?

Bateson and Punnett crossed two white- flowered lines and saw all purple flowers in the F1 generat They concluded this was an example of complementary gene interactions because a cross of the F1 plants yielded what ratio in the F2 generation?

Most people with the dominant mutant polydactyly allele have extra digits but at least 25% have the normal number of digits. What is the genetic explanation for this observation?

The amount of enzyme activity in a cell that is homozygous for a mutant allele is 400 units. The amount of enzyme activity in a cell homozygous for the WT allele is 200 units. The amount of enzyme activity in a heterozygote is 300 units. What is the dominance relationship between the WT and mutant allele for the phenotype of amount of enzyme per cell?

Alleles of the Sbe1 gene, which controls pea shape, can be detected by DNA analysis. In heterozygous plants, two distinct bands of DNA are visible. What is the relationship between the alleles of the heterozygote at the molecular level?

A metabolic reaction requires 40 units of enzymatic activity to proceed. If a dominant allele D can generate 40 units of enzyme and a mutant allele d" generates 20 units of enzyme, what can be said of the dominant wild- type allele?

Which mode of inheritance results in the phenotype of a heterozygote being indistinguishable from that of an organism homozygous for the dominant allele?

The amount of enzyme activity in a cell that is homozygous for a mutant allele is 0 units. The amount of enzyme activity in a cell homozygous for the WT allele is 200 units. The amount of enzyme activity in a heterozygote is 0 units. What type of allele is the mutant allele?

In Labrador retrievers, coat color is controlled by gene interaction in which homozygosity for a recessive allele can mask the phenotypic expression of a second gene. This genetic interaction is known as ___________and has a characteristic _________ ratio.