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What tests are indicated for cord blood specimens if the mother has made anti-K?


A) ABO, Rh, antibody screen
B) ABO, Rh, DAT
C) ABO, Rh, cold autoabsorption
D) Kleihauer-Betke

E) All of the above
F) B) and C)

Correct Answer

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In the event of a clinically significant antibody found in the mother's serum, which of the following must be performed to determine its concentration?


A) Fetal screen
B) Antibody screen
C) Antibody titer
D) Elution

E) A) and B)
F) A) and D)

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The most important serologic test for the diagnosis of HDFN is the with anti-IgG reagents.


A) elution
B) IAT
C) DAT
D) fetal screen

E) A) and D)
F) B) and C)

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All Rh-negative recipients who are transfused with as little as 1 mL of Rh-positive cells will develop anti-D.

A) True
B) False

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All of the following are true regarding antibody titration of maternal IgG antibodies except:


A) the method must include the indirect antiglobulin test.
B) the difference of two or more dilutions between titrations is considered significant.
C) red blood cells should consist of the same genotype for each titration.
D) the first serum specimen should be run in parallel with all subsequent titrations.

E) A) and C)
F) All of the above

Correct Answer

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Which of the following red blood cells is appropriate for neonatal transfusions?


A) Group A, CMV-negative
B) Group AB, CMV-negative
C) Group O, CMV+
D) Group O, CMV-negative

E) C) and D)
F) A) and C)

Correct Answer

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Why is the immediate spin eliminated in the prenatal antibody screen?


A) To reduce the detection of autoantibodies
B) To reduce the detection of IgG antibodies
C) To reduce the detection of IgM antibodies
D) None of the above

E) A) and D)
F) A) and C)

Correct Answer

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Which of the following reagents can be used to determine the immunoglobulin class of anti-M?


A) PEG
B) Chloroquine
C) 2-mercaptoethanol
D) Ficin

E) B) and D)
F) B) and C)

Correct Answer

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Rh-immune globulin should be given within how many hours after delivery?


A) 24
B) 48
C) 36
D) 72

E) B) and D)
F) B) and C)

Correct Answer

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In order for the mother to be considered for Rh-immune globulin, her Rh type must be , and her newborn must be .


A) Du-positive/Rh-positive
B) Rh-negative/Rh-positive
C) Du-negative/Du-negative
D) Rh-positive/Rh-negative

E) None of the above
F) B) and D)

Correct Answer

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Why is the Rh-positive firstborn of an Rh-negative mother unaffected by Rh hemolytic disease of the fetus and newborn (Rh HDFN) ?


A) The plasma volume of the mother is tripled during the first pregnancy which dilutes anti-D.
B) The titer of anti-D is too low to cause destruction of fetal antigens.
C) The mother has not been immunized to the D antigen before placental separation.
D) None of the above

E) All of the above
F) B) and C)

Correct Answer

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Active immunization induced by Rh(D) antigen can be prevented by the concurrent administration of:


A) gamma globulin.
B) Rh immunoglobulin.
C) alpha-1 protease inhibitor.
D) immune serum globulin.

E) B) and C)
F) A) and D)

Correct Answer

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How are units for exchange transfusion prepared?


A) Group O red blood cells and group O plasma
B) Group O red blood cells and group A plasma
C) Group O red blood cells and group AB plasma
D) Group O red blood cells and group B plasma

E) B) and D)
F) None of the above

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Why is reverse grouping omitted in neonate ABO grouping?


A) Maternal ABO antibody is identical to newborn ABO antibody.
B) Maternal antibodies mask the ABO antibodies of the neonate.
C) Newborns do not produce isoagglutinins of their own.
D) None of the above

E) None of the above
F) All of the above

Correct Answer

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A 300-µg dose of Rh-immune globulin contains sufficient anti-D to protect against how much whole blood?


A) 15 mL
B) 30 mL
C) 50 mL
D) 100 mL

E) All of the above
F) C) and D)

Correct Answer

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How is an intrauterine transfusion performed?


A) RBCs are injected into the placenta.
B) RBCs are injected into the fetal peritoneal cavity.
C) RBCs are injected into the maternal peritoneal cavity.
D) RBCs are injected into the mother and diffused through the placenta to the fetus.

E) C) and D)
F) A) and B)

Correct Answer

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An O-positive mother gave birth to an A- negative baby. After 24 hours the newborn's bilirubin level rose to 18 mg/dL. A DAT performed on the cord blood specimen was positive with polyspecific AHG and anti-IgG reagents. It is probable that from maternal circulation is coating the newborn's red blood cells.


A) anti-A, B
B) anti-B
C) anti-A
D) anti-D

E) All of the above
F) A) and B)

Correct Answer

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The D-positive fetal cells in Rh-HDN are .


A) homozygous
B) heterozygous
C) amorphic
D) homologous

E) A) and B)
F) A) and D)

Correct Answer

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All of the following are characteristic of ABO hemolytic disease of the fetus and newborn (HDFN) except:


A) the mother is group O.
B) the mother has anti-A,B.
C) the antibody is IgM.
D) the infant has mild HDFN.

E) None of the above
F) B) and C)

Correct Answer

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A cord blood specimen from a jaundiced infant should be tested for which of the following?


A) ABO
B) Rh
C) DAT
D) All of the above

E) A) and B)
F) A) and C)

Correct Answer

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